2012
2012-05-01
Leif Andersson elected as foreign associate to the National Academy of Sciences (USA)
2012-04-29
Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress
2012-04-26
Genes shed light on spread of agriculture in Stone Age
2012-04-22
Drug discovery using worms and digital image analysis
2012-04-13
Genetic adaptation of fat metabolism key to development of human brain
2012-04-05
Three-spined stickleback’s genes show adaptation to fresh water
2012-04-03
SciLifeLab to become a world leading research institute
2012-02-27
SciLifeLab gets news premises in Uppsala
2012-02-02
Ulf Landegren and Leif Andersson awarded ERC Advanced Grants
2012-02-01
SciLifeLab-DAY sets new visitor record!
2012-01-10
A great EU-funded project on regenerative medicine will be led by Uppsala scientists
2012-01-03
Researchers and companies meet to discuss diabetes
2011
2011-12-22
Genetic study of black chickens shed light on mechanisms causing rapid evolution in domestic animals
2011-12-15
Research strategies for Uppsala University 2013-2016
2011-12-12
Lars Rönnblom reveices grants from Ragnar Söderberg's foundation
2011-12-15
Research strategies for Uppsala University 2013-2016
2011-12-12
Lars Rönnblom reveices grants from Ragnar Söderberg's foundation
2011-12-08
Siv Andersson recieves Wallenberg Scholars
2011-12-07
Ulf Landegren and Leif Andersson awarded ERC advanced grant
2011-12-01
Orexo and Uppsala University Receive Swedish Research Council Grant for Bioceramics Project
2011-11-22
Ulf Landegren awarded "Björkénska priset"
2011-11-17
Kerstin Lindblad-Toh receives grants from Formas
2011-11-16
Tomas Axelsson receives grants from the Swedish Research Council; Research infrastructures
2011-11-01
Shared genes with Neanderthal relatives not unusual
2011-11-06
Lars Feuk: publication in Nature Structural and Moelcular Biology
2011-10-17
ERC Synergy Grant
2011-10-12
Millions of new regulatory elements found in human genome
2011-09-12
Lars Feuk receives grants from the European Research Council
Disciplinary Domain of Medicine and Pharmacy: News
2011-08-31
Lizard genome mapped for first time
Press release
2011-08-24
Well visited SciLifeLab-DAY
SciLifeLab Uppsala began the fall with the conference SciLifeLab-DAY. Approximately 230 scientists attended the conference, held twice a year for SciLifeLab members, one in January and one in August. The aim of SciLifeLab conferences is to build a strong community within life science research in Uppsala. Researchers in the community get the opportunity to meet and discuss both science and strategic perspectives.
Kerstin Lindblad-Toh, director of SciLifeLab in Uppsala, gave the opening talk entitled "Strategic discussion: What can we do now and where are we going". Two of the major biobanking initiatives, EpiHealth and Life Gene, were presented. The Ångström scientists Maria Strömme, Jöns Hilborn and Håkan Engqvist presented their research in biomaterials, and also a number of ongoing case studies were presented during the day. “Poster sessions” were combined with the coffee breaks and personnel both from the nine SciLifeLab technical platforms as well as from the Uppsala Biobank and the Berzelii Center were nearby to give information about their work.
2011-08-24
Exciting discovery about the origin of humans
2011-07-05
Publication in PNAS by Johan Elf
2011-06-16
SciLifeLab on Swedish Science Radio (Vetenskapsradion)
2011-06-14
SciLifeLab members at AIMDay® Cancer
2011-06-14
News from London: Exclusive Press Seminar on Stockholm-Uppsala-based Protein Research
2011-05-31
New Publication by Marene Landström
Researchers in Uppsala and Umeå have found a new signaling pathway activated by TGFβ that makes tumor cells more aggressive. The study, led by the SciLifeLab member Marene Landström, might open new possibilities for early detection of aggressive prostate tumors and novel therapeutic strategies. The article was published in Nature Communications 31 May 2011.
2011-05-25
Clinical Genetics at SciLifeLab
How new technologies could be introduced into clinical practice and how data storage and safety can be dealt with was some of the topics of the Clinical Genetics Day, organised by SciLifeLab. Kerstin Lindblad-Toh, Director of SciLifeLab in Uppsala, opened the seminar.
During the day both scientific topics, as well as ethics related to personal genome testing, were discussed. Invited speakers were: Niklas Dahl, Claes Wadelius, Ulf Gyllensten and Ola Spjuth from Uppsala university. Magnus Nordenskjöld, Anna Wedell and Yvonne Brandberg from Karolinska Institutet.
At the end of the day Anders Alderborn och Krister Halldin, EU- coordinators at Uppsala university, discussed the potential for SciLifeLab to apply for different EU-programs.
2011-05-11
SciLifeLab host for the Uppsala BIO-pub
The Uppsala-BIO pub the 11th of May was well attended, around 130 people came and listened to the evening's host, SciLifeLab.
During the evening both researchers and management from the SciLifeLab-team attended. Speakers were Maria Sörby, site director, and Ulf Landegren, vice director, both from SciLifeLab Uppsala, and also Jan Hörling from GE Healthcare.
Initially, the SciLifeLab organization, both at the management level and the technical platforms, were presented by Maria Sörby. Building the infrastructure surrounding the research is important for SciLifeLab, but also facilitating interdisciplinary research and initiating new types of research collaborations, both within the academia and all universities in Sweden, and also with industry and healthcare.
Ulf Landegren, vice director of SciLifeLab Uppsala, spoke about the techniques available within SciLifeLab. He also showed the different platforms available in Uppsala, which are already established since several years back and are run by experienced managers. He also stressed the importance of this type of greater cooperation, especially in an international competition.
After the presentations there was time for some refreshments and opportunities to meet people both from the academia and industry. Many took the opportunity to ask questions about SciLifeLab. There was also an opportunity to read about the activities of the nine technology platforms, which were presented on posters.
Wrinkled dog is key to new direction within inflammation research
An international research team led from Uppsala University and the Broad Institute of MIT and Harvard has discovered the gene underlying the characteristic wrinkled skin of the Shar-Pei dog. The same gene has been shown to be associated with a chronic fever condition that often afflicts members of the breed. The findings, which are interesting from a human health standpoint, were published today in PLoS Genetics.
Purebred dogs are bred on the basis of specific physical and behavioural characteristics. The selection process increases the likelihood that certain gene variants will be passed on, along with the risk for undesirable health issues.
The Shar-Pei’s thickened and wrinkled skin contains excess hyaluronic acid, probably due to over-activation of the HAS2 gene, one of the genes that govern production of hyaluronic acid. Members of the breed are often afflicted with a recurrent fever-like condition that bears resemblance to an auto-inflammatory fever condition in humans.
Researchers compared the breed’s genetic code with that of other breeds. They also compared the genetic code of healthy and afflicted Shar-Pei dogs. Both studies generated interesting results relating to the DNA region in which the HAS2 gene is located. In Shar-Pei dogs, multiple identical copies of a certain DNA segment were found in the proximity of this gene. No such duplications are present within other breeds.
“It was exciting to discover that the illness and the wrinkles share a genetic background,” says Mia Olsson, a doctoral student and the first author of the publication. “Multiple copies of the segment in the region in question increase the likelihood of the disease, which is probably caused by excess hyaluronic acid.”
The study also sheds light on the more general significance of hyaluronic acid for inflammatory diseases. The genetic background of approximately 60 per cent of cases involving certain human fever syndromes is unknown, making the connection between fever conditions and impaired control of the HAS2 gene very interesting.
“The findings open up a whole new area of research into inflammatory diseases in dogs and humans,” says Kerstin Lindblad Toh, director of the Science for Life Laboratory in Uppsala and a scientific director at the Broad Institute. “We have begun looking for the same mutation in human patients.”
The project was pursued within the framework of the Science for Life Laboratory (SciLifeLab) collaborative research initiative at Uppsala University. The study also involved collaboration with the Swedish University of Agricultural Sciences (SLU).
For more information, please contact:
Kerstin Lindblad Toh
Tel: +46-18-471 43 86 or +46-70-324 23 36
E-mail: kerstin.lindblad-toh@imbim.uu.se (currently in the U.S.)
Åke Hedhammar
Tel: +46-18-67 13 55
Press release published 2011-03-18
2011-03-14
The SciLifeLab in Uppsala Genomics Platform participates in ESGI
The SciLifeLab in Uppsala Genomics Platform participates in the recently launched European Sequencing and Genotyping Infrastucture (ESGI) which provides transnational access to sequencing and genotyping. For more information, contact A-C Syvänen (Ann-Christine.Syvanen@medsci.uu.se).
ESGI press release from 2011-03-14
2010
Johan Elf receives SFS-funding for "Future Research Leaders"
Uppsala consortium have been granted Wallenberg-foundation to study the structure of ribosomes
New model for how genes are regulated by small RNAs
Burning pain and itching governed by same nerve cells
We all know how hard it is not to scratch when we have an itch. But how can an itch be alleviated? In a new study published today in the prestigious
journal Neuron, researchers at Uppsala University present the surprising finding that the same nerve cells that are active when we experience heat pain are also associated with itching.
There are disorders and conditions that entail increased itching and can be extremely troublesome for those suffering from it. The mechanisms behind itching are not well understood today. For one thing, what is it about scratching that relieves itching?In the current study, which was performed on mice, the research team led by Professor Klas Kullander at the Department of Neuroscience examined the nerve cells that transfer heat pain. When these nerve cells had lost its capacity to signal, the mice reacted less to heat, as expected, but surprisingly they also started to itch incessantly.“These findings link together pain from a burn with regulating sensitivity to itching, which was highly surprising and interesting,” says Klas Kullander.Extreme itching is very unpleasant and difficult to treat. For example, it is a common complication following operations and burns. Eczema and other skin disorders can also lead to general itchiness. Greater knowledge of the underlying factors paves the way for developing new forms of treatment for itching, for example, activating pain fibers to reduce itching, which is supported by these findings.“In the long run, and with the help of more research, we will hopefully be able to fully elucidate what nerve fibers conduct the itching itself, and then we will be able to extinguish the itch at the source,” says Klas Kullander.For more information, please contact Professor Klas Kullander, phone: +46 (0)18-4714519, mobile: +46 (0)70-846 75 24, e-mail: klas.kullander@neuro.uu.se
New Publication by Johan Elf
Johan Elf, Uppsala researcher and SciLifeLab member has developed a significantly more accurate model that can be an important tool used in medical research. The study was published this week in the scientific journal PNAS. Read more
Thuréus Prize to Kerstin Lindblad-Toh
SciLifeLab Uppsalas director Kerstin Lindblad-Toh was awarded the Thuréus Prize by the Royal Society of Science in Uppsala (naturalhistory and medicine class).
Lars Wallentin honored with Gold Medal at the ESC Congress 2010
Proffesor Lars Wallentin was awarded the gold medal at annual European Society of Cardiology Congress 2010 for his "outstanding contribution to research in the development of cardiology".
Lars Wallentin is Professor of Cardiology at Uppsala University Hospital and the Uppsala Clinical Research Centre (UCR) at Uppsala University. Among his most important achievements is the development of new methods for diagnosis and treatment in acute coronary artery diseases, such as pioneering the use of molecular biomarkers in cardiology. He is the chief researcher of cardiovascular disease at UCR and leads several global clinical trials incorporating more than 60,000 patients worldwide.
Succesfull SciLifeLab day on the 20th of August 2010
Scientist from different departements at Uppsala University and Swedish University of Agricultural Sciences met with life science in focus in Geocentrum in Uppsala at the SciLifeLab day on the 20th of August 2010.
SciLifeLab Uppsala members, associated members and their group members gathered to discuss current scientific projects. SciLifeLab Uppsalas vice director Ulf Landegren was moderator during the seminars. Other lecturers were: Kerstin Lindblad-Toh (SciLifeLab-Uppsalas director), Aris Moustakas, Leif Andersson, Johan Elf, Staffan Svärd, Maréne Landström, Klas Kullander, Mattias Jakobsson, Sussanne Kerje, Lena Kjellén, Pernilla Bjerling, Siv Andersson, Agneta Siegbahn och Mats Nilsson.